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They are When a drug user's body has developed resistance to a certain drug that requires him/her to take more and more of it or a bigger dose over time in order to get "high" again, which leads to fatal overdoses, then you have developed (blank) to the drug

The strongest, most innovative tobacco control policies typically have originated at the local level before eventually being adopted at the state level

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Thus, the development of lesions are much more likely to have an invasive nature with the ability to metastasize