Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer
Sources: Sikiric et al., Curr Pharm Des 2018 | Chang et al., J Appl Physiol 2011 Security Profile & Chemical Identity Molecular specifications and preclinical safety data BPC-157 Chemical Identity Synthetic pentadecapeptide derived from human gastric juice BPC-157 Tolerance & Status Safety data from preclinical studies (rat, mouse, rabbit, dog) Published Preclinical Data 6 key studies published in J Orthop Res, J Appl Physiol, Curr Pharm Des, Growth Horm IGF Res and Am J Sports Med Biomechanics Significant improvement in tendon strength, stiffness and elasticity modulus at 14 days Achilles tendon repair (rat) Migration Dose-dependent acceleration of tendon fibroblast migration Tendon Repair Mechanisms Cytoprotection Novel cytoprotective mediator vascular recruitment and healing of the gastrointestinal tract Documented Gastroprotective Effects Important Notice Search Only Not intended for human consumption
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This propensity of infected erythrocytes to expose PS could be used to target antimalarials specifically to infected cells using peptides that accumulate predominantly in PS-exposing cells (Lawrence et al., 2018) or with liposomes conjugated to PS binding peptides (Tagami et al., 2015)
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If IV access isn't feasible, use NAC at 1800mg daily combined with oral milk thistle (silymarin) at 300600mg daily
