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2019 May;163:481-492

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Muscle Strength, Endurance & Sarcopenia Research (Scientific Reports, 2024) 5-Amino-1MQ Improves Aged Muscle Function Beyond Exercise Alone A study published in Scientific Reports by researchers at the University of Texas Medical Branch investigated 5-Amino-1MQ as an NNMT inhibitor in aged female mice to assess its effects on muscle strength and endurance

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Most people experience: Immediately: Small pinch First few hours: Mild soreness 24 hours: Tenderness improving 48 hours: Usually completely resolved Persistent pain is uncommon

The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M