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Nuclear Imaging For the evaluation of the BBB using radioisotopes, there are two main modalities: PET and SPECT

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The arginate (arginine salt) form demonstrates improved stability in gastric acid, making it better suited for oral administration with bioavailability exceeding 90% compared to roughly 3% for standard acetate taken orally

We collected data on study characteristics, summarized the quality of evidence, evaluated risk of bias of individual studies using the Newcastle Ottawa Scale, and investigated clinical sources of heterogeneity

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