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The reduced thymosin alpha-1 levels correspond to measurable impairment in regulatory T cell function, and regulatory T cell dysfunction is a recognized driver of psoriasis pathology

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It lacks electrolytes and is hypotonic, which can cause red blood cells to swell and rupture (hemolysis) if administered directly into the bloodstream

These mtDNA-depleted (Rho-0) cells showed the expected reduction in COX I, a mitochondrial genome-encoded protein, and also lacked detectable rHN peptide, strongly supporting its mitochondrial origin [2]