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There are anatomic differences in the lung that persist for years after smokers quit and gene activity also remains altered. Light Smokers and COPD Smokings effect on lung function explains why smokers are more likely to develop chronic obstructive pulmonary disease (COPD), which is diagnosed when lung function dips below a certain threshold

Furthermore, these neuropeptides act on nonneuronal cells to stimulate the release of additional proinflammatory mediators, including ATP, adenosine, bradykinin, prostaglandins, leukotrienes, histamine, tumor necrosis factor (TNF-), interleukin-1 (IL-1), proteases, and glutamate [121]

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