Jie Liu for technical support
doi:10.1016/j.abd.2021.02.004
Mechanistic pathways associated with acetaminophen-induced hepatotoxicity APAP is rapidly absorbed and extensively metabolized upon entering the liver, with 8590% conjugated with glucuronic acid or sulfate by the enzymes uridine diphosphate-glucuronosyltransferase and sulfotransferase and subsequently eliminated
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TXN and TXNRD1 were both strongly associated with metabolism, including glutathione and amino acid metabolisms