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These investigations occur exclusively in controlled, non-clinical in-vitro environments

Some B12 can also be absorbed passively in the intestines regardless of intrinsic factor, but this accounts for a small percentage

Nat Biotechnol 28(5):486494

[20] The practical upshot is a regulatory gray zone in which the substance is neither an approved drug nor an authorized compounding ingredient

If you are using a standard pill, you will need to be much stricter about taking it on a completely empty stomach to see any benefit

This overlap means that when taken together, they can interact in ways that require careful monitoring