Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition
J Pharm Sci 93:15371544 [DOI] [PubMed] [Google Scholar] Ebens A, Brose K, Leonardo ED, Hanson MG, Jr, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M
Intrathecal delivery of an adeno-associated viral vector serotype 9 (AAV9)-human SURF1 (hSURF1) has effectively corrected biochemical abnormalities in mouse models of SURF1 deficiency (107)
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KPV: As a fragment of alpha-MSH, an endogenous hormone, KPV inherits a theoretically favorable safety profile
Additionally, a 10-week study in overweight or obese post-menopausal women with prediabetes found that 250 mg NMN per day partially increased muscle insulin signaling and sensitivity, but no change in mitochondrial oxidative capacity was found 324