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380050) or a low-fat (lean) diet (LD

NNMT is strongly associated with metabolic regulation, adiposity, glucose balance, and energy expenditure in animal models

Specifically, researchers examined the effects of intra-articular injections of AOD9604, both alone and in combination with HA, on cartilage morphology, histopathology, and functional outcomes such as lameness

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At the cellular level, AOD-9604 exerts its primary effects through a complex mechanism involving beta-3 adrenergic receptors located on the surface of adipocytes (fat cells)

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