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About one fourth of young people experience a first-inhalation relaxation experience (FIRE) with their first cigarette, a large percentage of whom become addicted (DiFranza et al., 2007)

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Smoking exposes users to a complex mixture of toxic chemicals responsible for severe and often fatal diseases

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doi:10.1592/phco.30.6.585 Braggio C, Bocchialini G, Ventura L, Carbognani P, Rusca M, Ampollini L

Original research article: Cigarette Smoking Triggers Colitis by IFN-+ CD4+ T Cells Corresponding author: Hyunsu Bae REPUBLISHING GUIDELINES: Open access and sharing research is part of Frontiers mission