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Because the pancreas provides critical enzymes, as well as calcium required for vitamin B 12 absorption, pancreatic insufficiency may contribute to vitamin B 12 deficiency

It is utilized in laboratory research to study lipid metabolism, adipocyte activity, and metabolic signaling pathways

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It may have motivated George Whipple, who had a keen interest in liver diseases, to investigate the liver's role in hematopoiesis

While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

Altschul, S