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From an evolutionary perspective, the activation of the ACTH/HPA axis and sympathetic spinal system, along with the diminished function of the prefrontal cortex, results in a diminished ability to seek and experience pleasure, reduced food intake, decreased sexual activity, and sleep apnea

doi: 10.1016/j.neulet.2008.06.040, 21 CaiW.LiuL.ShiX.LiuY.WangJ.FangX.et al

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