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Age: absorption naturally slows as we get older, so timing can shift over the years

Marques AC, Vinckenbosch N, Brawand D, Kaessmann H (2008) Functional diversification of duplicate genes through subcellular adaptation of encoded proteins

It is thought that the link between levels of these hormones and prostate cancer may be due to their role in regulating prostate cell growth, function and survival

The step-wise dose increases exist to manage GI adaptation

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Because the liver is responsible for processing such a high volume of compounds, it requires a massive "cleanup crew" to prevent those compounds from damaging the liver's own tissues