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Nicotine, which is the addictive substance in cigarettes, releases a chemical in the brain known as dopamine, which is also know as the reward response and the reason why we become dependent on substances

Typically, three to five types of tobacco are obtained from the highest part of the plant and mixed to generate the signature flavour of a cigar

Eur J Pharmacol 278 : 1112 Madretsma GD et al