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The targeted 3-PLG-ibu-A-GSH and ibuprofen at higher, 1.5 M concentration (the estimated drug content of the 3-PLG-ibu-A-GSH nanocarriers) significantly protected against the barrier damaging effect of cytokines with the ibuprofen-coupled targeted nanocarrier group showing the highest effect against BBB dysfunction (Fig

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Further experiments have demonstrated that the peptide is capable of suppressing the activity of pro-inflammatory and fibrotic factors characteristic of the senescence-associated secretory phenotype (SASP), thereby contributing to the restoration of damaged tissue microenvironments