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A recent study has found that cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) are both protective and, confusingly, necessary for benzo[a]pyrene toxicity

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Smoking cannabis can cause unpleasant symptoms, including: chronic cough wheezing excess phlegm production acute bronchitis air bubbles in the lungs air pockets between the lungs and chest wall Using cannabis can also affect the immune system and increase a persons risk of lower respiratory tract infections

Goddard KAB, Feuer EJ, Mandelblatt JS, et al

To ensure rigour it incorporates available published data plus transparent assumptions based on international best practice where data gaps exist