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In the digestive tract, BPC-157 stabilizes tight-junction proteins (e.g., occludin) and reduces oxidative stress, supporting mucosal integrity

BPC-157 is a naturally occurring peptide derived from a protein found in the human stomach

Panel A highlights the bile acid axis, where bacterial enzymes like bile salt hydrolase (BSH) and 7-dehydroxylase remodel the bile acid pool (converting primary to secondary bile acids), influencing hepatic FXR and TGR5 signaling to regulate lipid metabolism and CYP7A1 expression

There are different resistance mechanisms reported in both pre-clinical and clinical studies

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