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Notably, this phenotype could not be rescued by adding exogenous IL-2 (40 U/ml) to costimulated T-cells (Figure 3C, right panel)

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Optimal dosing, frequency, and duration are completely unclear

This inhibition mode in hTYR is noteworthy, as it suggests that the search for and optimization of efficient and safe peptide-based inhibitors may become a key direction in the development of human tyrosinase inhibitors

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