Here is a more specific review of those issues
Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation
This might be perceived as a considerable problem, given that muscle disorders therapy has remained unresolved in general, and that there is neither a conceptual implementation of the original cytoprotection theory nor cytoprotective agents for therapy

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The treatment also decreased pro-inflammatory and pro-fibrotic gene expression with reduced macrophage infiltration (Li et al., 2025)
If your goal involves gastrointestinal healing, the peptide contacting intestinal tissues directly could provide benefit even if it never reaches the bloodstream