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But some pets, especially those with gastrointestinal disease, may not be able to absorb B12 effectively

Untested combinations: Novel or less-researched peptides lack even the limited safety information available for established compounds

As can be seen in Fig

The two peptides are also not the same kind of molecule

With oral vitamins it can take days or weeks of daily dosing to build up the same effect

For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation