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Much of this confusion can be attributed to the heterogeneity of the depressive syndrome, as many studies on nicotine and depression limit the clinical phenotype of depression

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Although dermal hyalinosis/sclerosis is a diagnostic criterion for LS, it may be missing in early lesions.[] Similarly, keratotic plugging may be more prevalent in the lesions of shorter duration.[] However, no correlation existed between the duration of disease process and histological criteria as also reported by Marren et al .[] Inflammation primarily comprised lymphocytes and can be present in lichenoid or diffuse pattern beneath the zone of subepithelial edema

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