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Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)

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The researchers said men who smoked one cigarette a day had about a 48% higher risk of developing coronary heart disease and were 25% more likely to have a stroke than those who had never smoked

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