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Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants

Glossary ABE Acyl-biotin exchange ABHD / Acyl-Rac acyl resin assisted capture AD Alzheimers disease AEG-1 Astrocyte elevated gene-1 AIDs Autoimmune diseases APE Acyl-PEG exchange APP Amyloid precursor protein APT Acyl protein thioesterase ASC Apoptosis-associated speck-like protein containing a CARD Atf3 Activating transcription factor 3 A Amyloid- BACE1 -site amyloid precursor protein-cleaving enzyme 1 CEGI Cattle encephalon glycoside cGAMP Cyclic GMP-AMP cGAS Cyclic GMP-AMP synthase CMA Chaperone-mediated autophagy CTD C-terminal containment domain DAMP Damage-associated molecular pattern DM Diabetes mellitus dTGN Dispersed TGN eNOS Endothelial nitric oxide synthase FAO Fatty acid oxidation FASN Fatty acid synthase Glut4 Glucose transporter 4 GRK6 protein-coupled receptor kinases 6 GSDMD Gasdermin-D HCC Hepatocellular carcinoma HSC70 Heat shock cognate protein of 70 kDa IBD Inflammatory bowel disease iE-DAP -d-glutamyl-meso-diaminopimelic acid IKK IB kinase IRAK Interleukin-1 receptor-associated kinase IRF3 Interferon regulatory factor 3 IRHOM2 Inactive rhomboid protein 2 KLF10 Kruppel-like factors 10 LCFAs Long-chain fatty acids LPS Lipopolysaccharide LRR Leucine-rich repeat LTP Long-term potentiation MAPK MAP kinases MASH Metabolic dysfunction-associated steatohepatitis MASLD Metabolic dysfunction-associated steatotic liver disease MAVS Mitochondrial antiviral-signaling protein MDP Muramyl dipeptide MTOC Microtubule organizing center MUC2 Mucin 2 MYD88 Myeloid differentiation primary response protein 88 NEK7 NIMA-associated kinase 7 NLR NOD-like receptor NOD Nucleotide-binding oligomerization domain NR2B N-methyl-D-aspartic acid receptor subunit 2B NTD N-terminal structural domain PAMP Pathogen-associated molecular pattern PAT Palmitoyl acyltransferase PD Parkinsons disease pDC Plasmacytoid dendritic cells PGN Peptidoglycan PPT Palmitoyl protein thioesterases PRDX5 Peroxiredoxin 5 PRDX6 Peroxiredoxin-6 PRRs Pattern recognition receptors PtdIns4P Phosphatidylinositol 4-phosphate PYD Pyridine structural domain RIPK2 Receptor-interacting serine/threonine-protein kinase 2 ROS Reactive oxygen species SLE Systemic lupus erythematosus SMPDL3B Sphingomyelin phosphodiesterase acid-like 3B STAT3 Signal transducer and activator of transcription 3 STING Stimulator of interferon genes SYT1 Synaptotagmin 1 TAB1 TAK1-binding protein TAK1 Transforming growth factor--activated protein kinase 1 TBK1 TANK-binding kinase 1 TGN Trans-Golgi network TLR Toll-like receptors TRAF6 Tumor necrosis factor receptor associated factor 6 TRPV2 Transient receptor potential vanilloid 2 ZDHHCs Zinc finger DHHC-containing proteins 1AR 1-adrenergic receptor S -synuclein

The United Kingdom held total 178 Advanced Therapy Medicinal Product (ATMP) clinical trials in 2022

This mechanism is different from acid-suppressing drugs like proton pump inhibitors (PPIs) or H2 blockers, which reduce acid production but do not affect the LES function directly

Diagnosis of Gout: Clinical, Laboratory, and Radiologic findings