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Related: Top Cancer Doc Gives 5 Lifestyle Strategies to Help You Avoid Cancer Smokers are likely to shave 10 to 15 years off their lives compared to nonsmokers, Cook says

Many studies have shown that smoking is one reason for a poor response to methotrexate, and that is dose-dependent

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In fact, murine studies have shown that exposure to cigarette smoke intensifies damage in the small intestine (83)