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Acknowledgements This work was supported by a Basic Science Research Program grant (NRF-2018R1D1A1B07048778) from the National Research Foundation of Korea

The development of a tolerance to the drug is a key concern

By implementing the premarket review requirement for new electronic nicotine delivery systems (ENDS) and other deemed new tobacco products, such as hookah and pipe tobacco, we are taking steps to transform the marketplace toward one where deemed new tobacco products available for sale will have undergone careful, science-based review and oversight by the FDA

Risks / unknowns: Low barrier to entry leads to high price competition

Researchers tested this idea by exposing anesthetized rats to smoke after cutting the vagus nerves

Yes, higher intake methods are more likely to cause it