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Conservative replication Parental RNA strands remain associated, and the codogenic positive-strand RNA is made first, followed by negative-strand synthesis on the positive-strand RNA template

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4A), which was also confirmed in PC cells with ectopic expression of SLC7A11 and Sec24 C (Fig

Lotiglipron was discontinued in 2023 owing to unfavourable pharmacokinetic drug-drug interaction data from two Phase I studies and to elevated transaminases indicative of liver dysfunction in a subset of patients 24