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However, arginine level depletion in patients sustained for about a week and returned to baseline level, suggesting that resistance on ADI-PEG20 may arise upon prolonged drug treatment [140, 141]

Adv Cancer Res (2014) 122:281320

ESE Hafez, T.N Evans (eds)

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These improvements correlate with histological findings of increased dermal thickness, enhanced collagen fiber organization, and reduced elastic fiber fragmentation