doi: 10.1016/j.mehy.2020.110412 34 CastejonA
Tight junctions are composed of transmembrane proteins, primarily Claudins, Occludin, and Junctional Adhesion Molecules (JAMs), which are anchored to the cell's internal cytoskeleton by scaffolding proteins like Zonula Occludens (ZO-1, ZO-2, and ZO-3)
All patients were instructed to apply a sunblock with sun protective factor (SPF) 50+ during the period of treatment and follow-up (3 months)
Activated JNK phosphorylates numerous cytoplasmic substrates, including cytoskeletal proteins and mitochondrial proteins like Bcl-2 and Bcl-xl, in addition to controlling a few transcription factors, including c-Jun, c-Fos, ATF-2, AP-1, p53, and Elk
In each case the model used is shown with the data presented
HUBERMAN: Where there are two to 100 beads, and each of those beads represents a different amino acid, and the arrangement of each amino acid relative to one another, that is their order along that string, determines what the peptide is and what the peptide does