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Topical use presents lower theoretical risk but should still be discussed with a healthcare provider

It also demonstrated cerebroprotective effects comparable to those of edaravone in a rat model of cerebral ischemia/reperfusion injury ( N -benzyl pyridinium moieties demonstrated significant in vitro acetylcholine inhibitory activity (with low activity toward butyrylcholinesterase) and antioxidant effect (Zondagh et al., 2020)

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After preliminary functional screening (see the following paragraphs), N -hexanoic-Tyr-Ile-(6) amino-hexanoic amide was chosen for further investigation with the expectation that it would be biologically active, metabolically stable, and BBB-permeable