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Studied for role in combating metabolic aging

However, the clinical heterogeneity observed in PEM suggests that other pathophysiological systems, such as coagulation cascade abnormalities, autonomic dysfunction, and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, may coexist within the same patient population and potentially interact with the mechanisms outlined in this framework

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Neurological symptoms: referral to a haematologist, with injections often around every two months