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Moreover, vitamin E slows down the ROS production (Bej et al., 2024a)

Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models

Conversely, GA significantly decreased the ISO-mediated expression of MMP-2 and -9 thereby contribute to the attenuation of cardiac fibrosis

Pietta PG (2000) Flavonoids as antioxidants

doi: 10.3390/antiox11061151 43 BinieckaMFoxEGaoWNgCTVealeDJFearonUet al