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Skin water content, transepidermal water loss (TEWL), skin elasticity, skin thickness, and the level of NMF constituents were determined in the SC at baseline and then at 12 weeks

Level A Anchor Evidence: Unlike the SCFAsmodule, the Bile Acid/Tryptophan module (and broader comprehensive metabolic reprogramming) lacks Level A closed-loop anchors that converge the causal chain to specific bile acid or indole metabolite molecules

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