In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration
Mazhabi et al., A label-free aptamer-based cytosensor for specific cervical cancer HeLa cell recognition through a gC 3 N 4AgI/ITO photoelectrode
Furthermore, OH generated via the Fenton reaction oxidize polyunsaturated fatty acids in the sperm membrane, producing malondialdehyde (MDA)
Targeting key signaling pathways in ROS homeostasis ROS homeostasis and the related signaling pathways occupy a central position in the pathogenesis of many diseases
Heresco-Levy, U., Ermilov, M., Lichtenberg, P., Bar, G
Safety: Both approaches have associated risks
