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The production of ROS and RNS plays a critical role in the pathophysiological processes leading to cochlear damage

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Thymosin beta-4 is a low-molecular-weight protein with a well-documented role in tissue repair processes, including wound healing, angiogenesis and peptide signaling, cellular proliferation and migration, re-epithelialization, and modulation of inflammatory responses

More recently, total thyroidectomy has been explored as a therapeutic option in patients with refractory symptoms, demonstrating sustained improvements in health-related quality of life compared to medical therapy