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4.4.4.5 Biomarker integration for disease staging and intervention monitoring The metabolite panel encompassing IS, pCS, PAGln, circulating BCAAs, and homocysteine provides a comprehensive readout of gut-liver-kidney axis dysregulation

10.1371/journal.pone.0028378 39 HalliwellB

The absence of visible irritation doesn't mean adaptation is finished

During ischemia, the lack of oxygen and nutrients leads to a depletion of ATP and the accumulation of metabolic waste products, creating a highly stressful environment for cardiac cells

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