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In: ColeLAButlerSA, editors

Bae H et al (2021) Flufenoxuron disturbs early pregnancy in pigs via induction of cell death with ER-mitochondrial dysfunction

Tissue effects (angiogenesis, VEGF-receptor signaling, growth factor cross-talk) persist much longer than the plasma window

PMID: 15100091 Yoshida T, Delafontaine P

In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

Herein, we report the preparation of aryl-fused BCHep scaffolds and establish that the geometry of the -naphthyl 9 is conserved in BCHep 10