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Description

On the one hand, BDNF/TrkB functions as a synergistic amplifier in PIK3CA-mutant or PTEN-loss tumors by engaging MAPK/ERK and JAK/STAT signaling [54], yielding dual phospho-signatures (p-AKT with p-ERK/JAKSTAT) and exhibiting combination-therapy synergy [55]

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1000 mg/day, P.O for 12 weeks) in patients with CHD [189, 190]

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