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Unlike the Cagri-CTR-Gs complexes, in the CagriBB-bound CTR H296 ECL2 adopted the inward rotamer position that was observed when bound to other non-lipidated peptides, and ECL3 formed the more closed conformation in both experimental repeats
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In an uncontrolled clinical trial in 23 women with rosacea, use of a topical 0.05% retinaldehyde cream once daily for six months led to modest improvement in rosacea-related facial redness and telangiectasia in 75% of participants
Author Contributions All named authors contributed equally to this manuscript
