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Discovery of AG-270, a first-in-class oral MAT2A inhibitor for the treatment of tumors with homozygous MTAP deletion

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However, 510% of breast cancer patients at their early diagnosis are found to have metastatic disease, and 2030% of patients have an increased chance of breast cancer recurrence over time [29,30]

History of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 represents absolute contraindications

Human trial results were inconsistent and variable