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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders [seeContraindications (4)andWarnings and Precautions (5.10)]

This process is a multifaceted and intricate regulatory mechanism, with multiple pathways mediating mitophagy demonstrating parallelism or redundancy to preserve the equilibrium between mitochondrial homeostasis and the mitochondrial quality control system (Figure 3)

This may reflect improved individual strand diameter as follicles produce more robust keratin structures

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