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The absence of human trials is a significant limitation

Long-standing GERD with significant esophageal damage may require longer treatment periods and show slower response compared to milder, more recent-onset reflux

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Human clinical evidence remains limited

From nine rats of each group, gingivomucosal tissue samples were collected from both the ligature and the non-ligature contralateral sides and vascular permeability was measured as described in Materials and Methods

But by normalizing the cytokine environment and supporting proper T-cell differentiation, it may create conditions more favorable for tolerance induction