The following factors may increase the likelihood of having a B12 deficiency
A decreased level of glutathione in the plasma is the result of an increased utilization of it inside the muscle, presumably to fight or "quench" any circulating free radicals
Extracellular vesicles derived from human Whartons jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid- oligomers
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons
Heat shock proteins (like HSP70 and HSP90), cytoskeletal components (like actin and tubulin), and ESCRT-associated proteins (such as Alix and TSG101) are some of the most common structural proteins in MEVs
Zhang Y, Zhang Z, Tu C, Chen X, He R