The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract
Rodier, Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
It is the so-called monoaminergic theory of depression that, with more difficulty, has also been attempted to be applied to psychoses (dopamine receptor alterations)
Always follow the instructions on your prescription label
The truth is more nuanced
An air bubble in the bloodstream can be deadly, as can a dose of medicine in the blood that is meant to be given in the skin