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A long-term real-world study showed that apremilast maintains efficacy for up to 52 weeks, exhibiting sustained PASI reductions and favorable tolerability (Radi et al

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D., Lenz, M., et al

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From the above findings, it was clarified that administration of the Si-based agent significantly relieved damage to the large intestine by suppressing the progression of inflammation

Instead, tracing the corresponding metabolic pathways, we found that those pathways were used to recycle sugars contained in glycans such as mannose, fucose, and glucosamine for use as substrates for viral replication (Supplementary Data 2)