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Since dopamine is critically involved in movement initiation and facilitation through its actions on both direct and indirect pathways in the basal ganglia circuitry [45,46,47], it is plausible to presume that a higher extracellular dopamine level should equate behavioral alterations such as an elevated level of voluntary movements

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The measure of bacterial metabolites such as butyrate in serum or feces is another approach, due to its role in enhancing colonic barrier function