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Standard esophageal HRM can be supplemented with adjunctive tests such as the multiple rapid swallow sequence, during which a patient is instructed to swallow water every 2 seconds for 5 swallows to assess inhibitory input and peristaltic reserve, and a rapid drink challenge to assess functional obstruction at the esophagogastric junction (EGJ)

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Hold for 5 to 10 seconds after the plunger is fully depressed before withdrawing the needle

(2) Aoyama K, Nakaki T