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doi: 10.1093/aje/kwv095 107 HetzC.ZhangK.KaufmanR

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In adults, neurologic symptoms of biotin deficiency include depression, lethargy, hallucinations, and numbness and tingling of the extremities (35)

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The protocol for a 3mL vial: draw the desired BAC water volume into a sterile needle and syringe, inject slowly down the side of the vial (not directly onto the lyophilized cake), allow the cake to dissolve without agitation, then gently swirl (never vortex) to ensure complete dissolution