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in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )

The dysregulated taurine levels seen in FM and ME/CFS may impair the ability of these patients to effectively manage oxidative stress, exacerbating mitochondrial dysfunction and contributing to the dysregulation of energy metabolism

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Seyedhassani SM et al (2010) No mitochondrial DNA deletions but more D-loop point mutations in repeated pregnancy loss

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The effect of multimorbidity patterns and the impact of comorbid anxiety and depression on primary health service use: the men androgen inflammation lifestyle environment and stress (MAILES) study