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In 2026, the Phase 3 SYNCHRONIZE-1 trial reported topline mean weight loss of about 16.6% at 76 weeks versus about 3.2% on placebo

BSO treatment, which inhibits the rate limiting enzyme for GSH synthesis, resulted in almost 80% reduction in extra mitochondrial GSH concentration compared to about 50% reduction in the mitochondrial GSH pool suggesting that cytosolic GSH is more sensitive to BSO compared to mitochondrial GSH

Discovery of a small-molecule toxin with inhibitory activity at human P2X4 ion channels

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